Anticorpi MLKL

13 prodotti

MLKL è un gene codificato dal simbolo MLKL. Comunemente indicato anche come: Mixed lineage kinase domain-like protein; hMLKL. MLKL ha una massa di 54.48kDa e una lunghezza di amminoacidi di 471.

Offriamo 13 anticorpi contro MLKL, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610).
Sommario di Entrez
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Somiglianze di sequenza
Belongs to the protein kinase superfamily.
Modifica post-translazionale
Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Posizione cellulare
Cytoplasm. Cell membrane.

Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Collegamenti al database
Western Blot - Anti-MLKL Antibody (A9717) - Antibodies.com
Western Blot - Anti-MLKL Antibody (A92971) - Antibodies.com
(3)
Western Blot - Anti-MLKL Antibody (A90445) - Antibodies.com
(2)
Western Blot - Anti-MLKL Antibody (A90295) - Antibodies.com
(2)
Western Blot - Anti-MLKL (phospho Ser454) Antibody (A305626) - Antibodies.com
Western Blot - Anti-MLKL Antibody (A307138) - Antibodies.com
Visualizza prodottoKnockout convalidato
Western Blot - Anti-MLKL (phospho Ser358) Antibody (A308391) - Antibodies.com
Western Blot - Anti-MLKL (phospho Ser441) Antibody (A305778) - Antibodies.com
Western Blot - Anti-MLKL Antibody [ARC0165] (A308816) - Antibodies.com
Anti-MLKL Antibody from Bioworld Technology (BS9822M) - Antibodies.com
(2)
Western blot - MLKL antibody from Signalway Antibody (38674) - Antibodies.com
Western blot - MLKL Polyclonal Antibody from Signalway Antibody (41150) - Antibodies.com
MLKL Antibody from Signalway Antibody (35441) - Antibodies.com

Mostra 1-13 di 13 prodotti

Filtri Menù Principale Contattaci 0Check-out
Inizio pagina