Anticorpi MICA

12 prodotti

MICA è un gene codificato dal simbolo MICA. Comunemente indicato anche come: MHC class I polypeptide-related sequence A; MIC-A; PERB11.1. MICA ha una massa di 42.92kDa, una lunghezza di amminoacidi di 383, ed è implicato nella malattia: Psoriasis 1; Psoriatic arthritis.

Offriamo 12 anticorpi contro MICA, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Sommario di Entrez
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants.
Specificità del tessuto
Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.
Coinvolgimento nella malattia
Psoriasis 1: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis.

Psoriatic arthritis: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Somiglianze di sequenza
Belongs to the MHC class I family. MIC subfamily.
Modifica post-translazionale
N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
Posizione cellulare
Cell membrane. Cytoplasm.

Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum.
Collegamenti al database
SDS-PAGE - Anti-MICA Antibody [CLN-619] - Low endotoxin, Azide free (A324149) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-MICA Antibody [MICA/4442] - BSA and Azide free (A278114) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MICA Antibody [MICA/4442] (A277526) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MICA Antibody [MICA/4443] - BSA and Azide free (A278115) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MICA Antibody [MICA/4443] (A277527) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-MICA Antibody [ARC2422] (A306195) - Antibodies.com
(2)
Western Blot - Anti-MICA Antibody (A13443) - Antibodies.com
Western Blot - Anti-MICA Antibody (A90268) - Antibodies.com
Flow Cytometry - Anti-MICA Antibody [DM157] - Azide free (A318551) - Antibodies.com
Visualizza prodottoAnticorpo ricombinante
Western blot - MICA Antibody from Signalway Antibody (24546) - Antibodies.com
(2)
Anti-MICA Antibody from Bioworld Technology (BS6664) - Antibodies.com
Western blot - MICA antibody from Signalway Antibody (38237) - Antibodies.com

Mostra 1-12 di 12 prodotti

Filtri Menù Principale Contattaci 0Check-out
Inizio pagina