Mesothelin è un gene codificato dal simbolo MSLN. Comunemente indicato anche come: CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; MSLN; MPF. Mesothelin ha una massa di 68.99kDa e una lunghezza di amminoacidi di 630.
Offriamo 36 anticorpi contro Mesothelin, allevati nel Coniglio, Topo, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Membrane-anchored forms may play a role in cellular adhesion.
Sommario di Entrez
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Specificità del tessuto
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Somiglianze di sequenza
Belongs to the mesothelin family.
Modifica post-translazionale
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Posizione cellulare
Cell membrane. Golgi apparatus.
