Anticorpi MERTK

32 prodotti

MERTK è un gene codificato dal simbolo MERTK. Comunemente indicato anche come: Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MER. MERTK ha una massa di 110.25kDa, una lunghezza di amminoacidi di 999, ed è implicato in Retinitis pigmentosa 38.

Offriamo 32 anticorpi contro MERTK, allevati nel Coniglio, Topo, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Sommario di Entrez
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Specificità del tessuto
Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
Coinvolgimento nella malattia
Retinitis pigmentosa 38: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Modifica post-translazionale
Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
Posizione cellulare
Membrane.
Western Blot - Anti-MERTK Antibody (A11835) - Antibodies.com
(4)
SDS-PAGE - Anti-MERTK Antibody [RGX-019] - Low endotoxin, Azide free (A324142) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3022] (A248118) - Antibodies.com
(4)
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3015] - BSA and Azide free (A251300) - Antibodies.com
(4)
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3015] (A248117) - Antibodies.com
(4)
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3022] - BSA and Azide free (A251301) - Antibodies.com
(4)
Western Blot - Anti-MERTK Antibody (C21157) - Antibodies.com
(2)
Visualizza prodotto10µg Dimensione di prova
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] (A277531) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MERTK Antibody (A83923) - Antibodies.com
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3023] - BSA and Azide free (A278118) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3023] (A277530) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free (A278119) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Western Blot - Anti-MERTK Antibody (R12-3015) - Antibodies.com
Visualizza prodotto10µg Dimensione di prova
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Visualizza prodottoAnticorpo ricombinante
Western Blot - Anti-MERTK Antibody [ARC0229] (A307378) - Antibodies.com
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Anti-MERTK Antibody from FabGennix (MKT-121AP) - Antibodies.com
(2)
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Western blot - MerTK/Tyro3 (Phospho-Tyr749/681) Polyclonal Antibody from Signalway Antibody (12338) - Antibodies.com
Anti-MERTK Antibody from FabGennix (MKT-101AP) - Antibodies.com
(2)
Anti-MerTK Antibody from Bioworld Technology (BS9846M) - Antibodies.com
(2)
Anti-MerTK Antibody from Bioworld Technology (BS7162) - Antibodies.com
Anti-MERTK Antibody from FabGennix (MKT-112AP) - Antibodies.com
Anti-MerTK Antibody from Bioworld Technology (BS60376) - Antibodies.com
Western blot - MERTK Antibody from Signalway Antibody (32851) - Antibodies.com
Western blot - MERTK Antibody from Signalway Antibody (35290) - Antibodies.com
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