MEK5 è un gene codificato dal simbolo MAP2K5. Comunemente indicato anche come: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MEK 5; MAP2K5; MKK5; PRKMK5. MEK5 ha una massa di 50.11kDa e una lunghezza di amminoacidi di 448.
Offriamo 7 anticorpi contro MEK5, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo, Ratto, Bovino, Pollo, Cane, Xenopus e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
Sommario di Entrez
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
Specificità del tessuto
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Modifica post-translazionale
Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
