MCAK è un gene codificato dal simbolo KIF2C. Comunemente indicato anche come: Kinesin-like protein KIF2C; Kinesin-like protein 6; Mitotic centromere-associated kinesin; KIF2C; KNSL6. MCAK ha una massa di 81.31kDa e una lunghezza di amminoacidi di 725.
Offriamo 40 anticorpi contro MCAK, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).
Sommario di Entrez
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.
Somiglianze di sequenza
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.
Modifica post-translazionale
Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.
Posizione cellulare
Cytoplasm > Cytoskeleton. Nucleus. Chromosome > Centromere. Chromosome > Centromere > Kinetochore.
Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.
