MAGEA4 è un gene codificato dal simbolo MAGEA4. Comunemente indicato anche come: Melanoma-associated antigen 4; Cancer/testis antigen 1.4; CT1.4; MAGE-4 antigen; MAGE-41 antigen; MAGE-X2 antigen; MAGE4. MAGEA4 ha una massa di 34.9kDa e una lunghezza di amminoacidi di 317.
Offriamo 7 anticorpi contro MAGEA4, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression.
Sommario di Entrez
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.
Specificità del tessuto
Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta.
