MAdCAM1 è un gene codificato dal simbolo MADCAM1. Comunemente indicato anche come: Mucosal addressin cell adhesion molecule 1; MAdCAM-1. MAdCAM1 ha una massa di 40.16kDa e una lunghezza di amminoacidi di 382.
Offriamo 10 anticorpi contro MAdCAM1, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
Sommario di Entrez
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
Specificità del tessuto
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Modifica post-translazionale
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Posizione cellulare
Membrane.
