LASP1 è un gene codificato dal simbolo LASP1. Comunemente indicato anche come: LIM and SH3 domain protein 1; LASP-1; Metastatic lymph node gene 50 protein; MLN 50; MLN50. LASP1 ha una massa di 29.72kDa e una lunghezza di amminoacidi di 261.
Offriamo 6 anticorpi contro LASP1, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Sommario di Entrez
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer.
Posizione cellulare
Cytoplasm > Cell cortex. Cytoplasm > Cytoskeleton.
Associated with the F-actin rich cortical cytoskeleton.
