Kallikrein 4 è un gene codificato dal simbolo KLK4. Comunemente indicato anche come: Kallikrein-4; Enamel matrix serine proteinase 1; Kallikrein-like protein 1; KLK-L1; Prostase; Serine protease 17; KLK4; EMSP1; PRSS17; PSTS. Kallikrein 4 ha una massa di 27.03kDa, una lunghezza di amminoacidi di 254, ed è implicato in Amelogenesis imperfecta, hypomaturation type, 2A1.
Offriamo 7 anticorpi contro Kallikrein 4, allevati nel Coniglio, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).
Sommario di Entrez
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene.
Specificità del tessuto
Expressed in prostate.
Coinvolgimento nella malattia
Amelogenesis imperfecta, hypomaturation type, 2A1: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.
Somiglianze di sequenza
Belongs to the peptidase S1 family. Kallikrein subfamily.
Modifica post-translazionale
N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues.
Posizione cellulare
Secreted.
