IRF2 è un gene codificato dal simbolo IRF2. Comunemente indicato anche come: Interferon regulatory factor 2; IRF-2. IRF2 ha una massa di 39.35kDa e una lunghezza di amminoacidi di 349.
Offriamo 8 anticorpi contro IRF2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Sommario di Entrez
IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
Specificità del tessuto
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Somiglianze di sequenza
Belongs to the IRF family.
Modifica post-translazionale
Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity.
Posizione cellulare
Nucleus.
