IRE1 è un gene codificato dal simbolo ERN1. Comunemente indicato anche come: Serine/threonine-protein kinase/endoribonuclease Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p-alphaa; ERN1. IRE1 ha una massa di 109.74kDa e una lunghezza di amminoacidi di 977.
Offriamo 15 anticorpi contro IRE1, allevati nel Coniglio, Capra e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464, PubMed:11175748, PubMed:12637535, PubMed:9637683, PubMed:21317875). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464, PubMed:24508390, PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464, PubMed:24508390, PubMed:21317875). Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A (PubMed:21884936, PubMed:28067262).
Specificità del tessuto
Ubiquitously expressed. High levels observed in pancreatic tissue.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Modifica post-translazionale
Autophosphorylated following homodimerization. Autophosphorylation promotes activation of the endoribonuclease domain.
Posizione cellulare
Endoplasmic reticulum membrane.
