IRAKM è un gene codificato dal simbolo IRAK3. Comunemente indicato anche come: Interleukin-1 receptor-associated kinase 3; IRAK-3; IL-1 receptor-associated kinase M; IRAK-M; IRAK3. IRAKM ha una massa di 67.77kDa, una lunghezza di amminoacidi di 596, ed è implicato in Asthma-related traits 5.
Offriamo 11 anticorpi contro IRAKM, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Sommario di Entrez
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
Specificità del tessuto
Expressed predominantly in peripheral blood lymphocytes.
Coinvolgimento nella malattia
Asthma-related traits 5: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
