Integrin alpha 2 è un gene codificato dal simbolo ITGA2. Comunemente indicato anche come: Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; ITGA2; CD49B. Integrin alpha 2 ha una massa di 129.3kDa e una lunghezza di amminoacidi di 1181.
Offriamo 15 anticorpi contro Integrin alpha 2, allevati nel Coniglio, Topo e Ratto, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Sommario di Entrez
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Somiglianze di sequenza
Belongs to the integrin alpha chain family.
Posizione cellulare
Membrane.
