IL-17a è un gene codificato dal simbolo IL17A. Comunemente indicato anche come: Interleukin-17A; IL-17; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8; IL17A; CTLA8; IL17. IL-17a ha una massa di 17.5kDa e una lunghezza di amminoacidi di 155.
Offriamo 37 anticorpi contro IL-17a, allevati nel Coniglio, Topo, Ratto, Pollo e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Pecora, Cane, Goat, Porcellino d'India, Cavallo e Primati.
Informazioni su geni e proteine
Riepilogo UniProt
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).
Sommario di Entrez
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Specificità del tessuto
Restricted to activated memory T-cells.
Somiglianze di sequenza
Belongs to the IL-17 family.
Modifica post-translazionale
Found both in glycosylated and nonglycosylated forms.
Posizione cellulare
Secreted.
