IKB beta è un gene codificato dal simbolo NFKBIB. Comunemente indicato anche come: NF-kappa-B inhibitor beta; NF-kappa-BIB; I-kappa-B-beta; IkB-B; Thyroid receptor-interacting protein 9; TR-interacting protein 9; NFKBIB; IKBB; TRIP9. IKB beta ha una massa di 37.77kDa e una lunghezza di amminoacidi di 356.
Offriamo 7 anticorpi contro IKB beta, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Sommario di Entrez
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
Specificità del tessuto
Expressed in all tissues examined.
Somiglianze di sequenza
Belongs to the NF-kappa-B inhibitor family.
Modifica post-translazionale
Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation.
Posizione cellulare
Cytoplasm. Nucleus.
