ICOS Ligand è un gene codificato dal simbolo ICOSLG. Comunemente indicato anche come: B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; ICOSLG; B7H2; B7RP1; ICOSL; KIAA0653. ICOS Ligand ha una massa di 33.35kDa e una lunghezza di amminoacidi di 302.
Offriamo 7 anticorpi contro ICOS Ligand, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Specificità del tessuto
Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
Somiglianze di sequenza
Belongs to the immunoglobulin superfamily. BTN/MOG family.
Posizione cellulare
Cell membrane.
