ICAM3 è un gene codificato dal simbolo ICAM3. Comunemente indicato anche come: Intercellular adhesion molecule 3; ICAM-3; CDw50; ICAM-R. ICAM3 ha una massa di 59.54kDa e una lunghezza di amminoacidi di 547.
Offriamo 31 anticorpi contro ICAM3, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Sommario di Entrez
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Leukocytes.
Somiglianze di sequenza
Belongs to the immunoglobulin superfamily. ICAM family.
Modifica post-translazionale
Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.
Posizione cellulare
Membrane.
