ICAD è un gene codificato dal simbolo DFFA. Comunemente indicato anche come: DNA fragmentation factor subunit alpha; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; DFFA; DFF1; DFF45. ICAD ha una massa di 36.52kDa e una lunghezza di amminoacidi di 331.
Offriamo 13 anticorpi contro ICAD, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Inhibitor of the caspase-activated DNase (DFF40).
Sommario di Entrez
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Modifica post-translazionale
Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
Posizione cellulare
Cytoplasm.
