Hsp105 è un gene codificato dal simbolo HSPH1. Comunemente indicato anche come: Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP110; KIAA0201. Hsp105 ha una massa di 96.87kDa e una lunghezza di amminoacidi di 858.
Offriamo 6 anticorpi contro Hsp105, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Sommario di Entrez
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
Specificità del tessuto
Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
Somiglianze di sequenza
Belongs to the heat shock protein 70 family.
Modifica post-translazionale
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
Posizione cellulare
Cytoplasm.
