HMG14 è un gene codificato dal simbolo HMGN1. Comunemente indicato anche come: Non-histone chromosomal protein HMG-14; High mobility group nucleosome-binding domain-containing protein 1; HMGN1. HMG14 ha una massa di 10.66kDa e una lunghezza di amminoacidi di 100.
Offriamo 6 anticorpi contro HMG14, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).
Sommario di Entrez
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes.
Somiglianze di sequenza
Belongs to the HMGN family.
Modifica post-translazionale
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Posizione cellulare
Nucleus. Cytoplasm.
Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
