Histone H4 è un gene codificato dal simbolo H4C1. Comunemente indicato anche come: H4C1; H4/A; H4FA; HIST1H4A. Histone H4 ha una massa di 11.37kDa e una lunghezza di amminoacidi di 103.
Offriamo 71 anticorpi contro Histone H4, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, IP, Dot e ChIP con campioni derivati da Umano, Topo, Ratto, Scimmia, Drosofila e Stabilimenti.
Informazioni su geni e proteine
Riepilogo UniProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Sommario di Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element.
Somiglianze di sequenza
Belongs to the histone H4 family.
Modifica post-translazionale
Acetylation at Lys-6 (H4K5ac), Lys-9 (H4K8ac), Lys-13 (H4K12ac) and Lys-17 (H4K16ac) occurs in coding regions of the genome but not in heterochromatin.
Posizione cellulare
Nucleus. Chromosome.
