Histone H2A.Z è un gene codificato dal simbolo H2AZ1. Comunemente indicato anche come: H2A/z; H2AZ1; H2AFZ; H2AZ. Histone H2A.Z ha una massa di 13.55kDa e una lunghezza di amminoacidi di 128.
Offriamo 12 anticorpi contro Histone H2A.Z, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA, ICC/IF, IP e ChIP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Sommario di Entrez
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality.
Somiglianze di sequenza
Belongs to the histone H2A family.
Modifica post-translazionale
Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.
Posizione cellulare
Nucleus. Chromosome.
