Hexokinase II è un gene codificato dal simbolo HK2. Comunemente indicato anche come: Hexokinase-2; Hexokinase type II; HK II; Hexokinase-B; Muscle form hexokinase; HK2. Hexokinase II ha una massa di 102.38kDa e una lunghezza di amminoacidi di 917.
Offriamo 8 anticorpi contro Hexokinase II, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175).
Sommario di Entrez
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells.
Specificità del tessuto
Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle.
Somiglianze di sequenza
Belongs to the hexokinase family.
Posizione cellulare
Mitochondrion outer membrane. Cytoplasm > Cytosol.
The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880). The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880). Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175).
