Hepatitis B Virus Surface Antigen è un gene codificato dal simbolo S. Comunemente indicato anche come: Large envelope protein; L glycoprotein; L-HBsAg; LHB; Large S protein; Large surface protein; Major surface antigen; S. Hepatitis B Virus Surface Antigen ha una massa di 42.35kDa e una lunghezza di amminoacidi di 389.
Offriamo 9 anticorpi contro Hepatitis B Virus Surface Antigen, allevati nel Coniglio, Topo e Human, che sono adatti per IHC, ELISA e ICC/IF con campioni derivati da Umano.
Informazioni su geni e proteine
Riepilogo UniProt
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
Somiglianze di sequenza
Belongs to the orthohepadnavirus major surface antigen family.
Modifica post-translazionale
Isoform M is N-terminally acetylated by host at a ratio of 90%, and N-glycosylated by host at the pre-S2 region.
Posizione cellulare
Virion membrane.
Uso biotecnologico
Systematic vaccination of individuals at risk of exposure to the virus has been the main method of controlling the morbidity and mortality associated with hepatitis B. The first hepatitis B vaccine was manufactured by the purification and inactivation of HBsAg obtained from the plasma of chronic hepatitis B virus carriers. The vaccine is now produced by recombinant DNA techniques and expression of the S isoform in yeast cells. The pre-S region do not seem to induce strong enough antigenic response.
