Heparin Cofactor II è un gene codificato dal simbolo SERPIND1. Comunemente indicato anche come: Heparin cofactor 2; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1; SERPIND1; HCF2. Heparin Cofactor II ha una massa di 57.07kDa, una lunghezza di amminoacidi di 499, ed è implicato in Thrombophilia due to heparin cofactor 2 deficiency.
Offriamo 6 anticorpi contro Heparin Cofactor II, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
Sommario di Entrez
This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.
Specificità del tessuto
Expressed predominantly in liver. Also present in plasma.
Coinvolgimento nella malattia
Thrombophilia due to heparin cofactor 2 deficiency: A hemostatic disorder characterized by a tendency to recurrent thrombosis.
Somiglianze di sequenza
Belongs to the serpin family.
Modifica post-translazionale
Phosphorylated by FAM20C in the extracellular medium.
