Heme Oxygenase 1 è un gene codificato dal simbolo HMOX1. Comunemente indicato anche come: HO-1; HMOX1; HO; HO1. Heme Oxygenase 1 ha una massa di 32.82kDa, una lunghezza di amminoacidi di 288, ed è implicato in Heme oxygenase 1 deficiency.
Offriamo 16 anticorpi contro Heme Oxygenase 1, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Coniglio, Scimmia, Cane, Porcellino d'India e Criceto.
Informazioni su geni e proteine
Riepilogo UniProt
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
Sommario di Entrez
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.
Specificità del tessuto
Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
Coinvolgimento nella malattia
Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly.
Somiglianze di sequenza
Belongs to the heme oxygenase family.
Posizione cellulare
Microsome. Endoplasmic reticulum membrane.
