GSTM2 è un gene codificato dal simbolo GSTM2. Comunemente indicato anche come: Glutathione S-transferase Mu 2; GST class-mu 2-2; GST4. GSTM2 ha una massa di 25.75kDa e una lunghezza di amminoacidi di 218.
Offriamo 6 anticorpi contro GSTM2, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Sommario di Entrez
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.
Specificità del tessuto
Muscle.
Somiglianze di sequenza
Belongs to the GST superfamily. Mu family.
Posizione cellulare
Cytoplasm.
