GRK2 è un gene codificato dal simbolo GRK2. Comunemente indicato anche come: Beta-adrenergic receptor kinase 1; Beta-ARK-1; G-protein coupled receptor kinase 2; ADRBK1; BARK; BARK1. GRK2 ha una massa di 79.57kDa e una lunghezza di amminoacidi di 689.
Offriamo 19 anticorpi contro GRK2, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo, Ratto e Cane.
Informazioni su geni e proteine
Riepilogo UniProt
Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity).
Sommario di Entrez
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Specificità del tessuto
Expressed in peripheral blood leukocytes.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Posizione cellulare
Cytoplasm. Cell membrane.
