GRIK1 è un gene codificato dal simbolo GRIK1. Comunemente indicato anche come: Glutamate receptor ionotropic, kainate 1; GluK1; Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GLUR5. GRIK1 ha una massa di 103.98kDa e una lunghezza di amminoacidi di 918.
Offriamo 9 anticorpi contro GRIK1, allevati nel Coniglio, che sono adatti per WB, IHC e ELISA con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Sommario di Entrez
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.
Specificità del tessuto
Most abundant in the cerebellum and the suprachiasmatic nuclei (SCN) of the hypothalamus.
Somiglianze di sequenza
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
Posizione cellulare
Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane.
