GRB2 è un gene codificato dal simbolo GRB2. Comunemente indicato anche come: Growth factor receptor-bound protein 2; Adapter protein Protein Ash; SH2/SH3 adapter ASH. GRB2 ha una massa di 25.21kDa e una lunghezza di amminoacidi di 217.
Offriamo 16 anticorpi contro GRB2, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Maiale e Scimmia.
Informazioni su geni e proteine
Riepilogo UniProt
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
Sommario di Entrez
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the GRB2/sem-5/DRK family.
Posizione cellulare
Nucleus. Cytoplasm. Endosome. Golgi apparatus.
