Anticorpi Granulin

8 prodotti

Granulin è un gene codificato dal simbolo GRN. Comunemente indicato anche come: ProPGRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda; GP88 precursor; PC cell-derived growth factor; PCDGF; Proepithelin; PEPI; GRN. Granulin ha una massa di 63.54kDa, una lunghezza di amminoacidi di 593, ed è implicato nella malattia: Ubiquitin-positive frontotemporal dementia; Ceroid lipofuscinosis, neuronal, 11.

Offriamo 8 anticorpi contro Granulin, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771).
Sommario di Entrez
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Specificità del tessuto
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Coinvolgimento nella malattia
Ubiquitin-positive frontotemporal dementia: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

Ceroid lipofuscinosis, neuronal, 11: A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.
Somiglianze di sequenza
Belongs to the granulin family.
Modifica post-translazionale
Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (PubMed:12526812, PubMed:28743268). Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28743268).
Posizione cellulare
Secreted. Lysosome.

Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity).
Western Blot - Anti-Granulin Antibody (A91257) - Antibodies.com
(2)
Western Blot - Anti-Granulin Antibody [ARC51129] (A305510) - Antibodies.com
Western Blot - Anti-Granulin Antibody (A11875) - Antibodies.com
Immunofluorescence - Anti-Granulin Antibody (A84597) - Antibodies.com
Western Blot - Anti-Granulin Antibody [ARC59451] (A309379) - Antibodies.com
(2)
Western Blot - Anti-Progranulin Antibody (A82530) - Antibodies.com
Anti-GRN Antibody from Bioworld Technology (BS7852) - Antibodies.com
Western blot - GRN Antibody from Signalway Antibody (33035) - Antibodies.com

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