GM-CSF Receptor alpha è un gene codificato dal simbolo CSF2RA. Comunemente indicato anche come: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF-R-alpha; CDw116; CSF2RA; CSF2R; CSF2RY. GM-CSF Receptor alpha ha una massa di 46.21kDa, una lunghezza di amminoacidi di 400, ed è implicato in Pulmonary surfactant metabolism dysfunction 4.
Offriamo 13 anticorpi contro GM-CSF Receptor alpha, allevati nel Coniglio, Topo e Human, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Sommario di Entrez
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
Coinvolgimento nella malattia
Pulmonary surfactant metabolism dysfunction 4: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.
Somiglianze di sequenza
Belongs to the type I cytokine receptor family. Type 5 subfamily.
Posizione cellulare
Cell membrane.
