Glucose Transporter GLUT2 è un gene codificato dal simbolo SLC2A2. Comunemente indicato anche come: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2; SLC2A2; GLUT2. Glucose Transporter GLUT2 ha una massa di 57.49kDa, una lunghezza di amminoacidi di 524, ed è implicato in Fanconi-Bickel syndrome.
Offriamo 12 anticorpi contro Glucose Transporter GLUT2, allevati nel Coniglio e Capra, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:8027028, PubMed:16186102, PubMed:23396969, PubMed:28083649). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate (PubMed:23396969).
Sommario di Entrez
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.
Specificità del tessuto
Liver, insulin-producing beta cell, small intestine and kidney.
Coinvolgimento nella malattia
Fanconi-Bickel syndrome: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose.
Somiglianze di sequenza
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Modifica post-translazionale
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells.
Posizione cellulare
Cell membrane.
