Glucagon Receptor è un gene codificato dal simbolo GCGR. Comunemente indicato anche come: GL-R; GCGR. Glucagon Receptor ha una massa di 54.01kDa e una lunghezza di amminoacidi di 477.
Offriamo 7 anticorpi contro Glucagon Receptor, allevati nel Coniglio e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Sommario di Entrez
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 2 family.
Modifica post-translazionale
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.
Posizione cellulare
Cell membrane.
Is rapidly internalized after ligand-binding.
