GLP1R è un gene codificato dal simbolo GLP1R. Comunemente indicato anche come: Glucagon-like peptide 1 receptor; GLP-1 receptor. GLP1R ha una massa di 53.03kDa e una lunghezza di amminoacidi di 463.
Offriamo 8 anticorpi contro GLP1R, allevati nel Coniglio, Capra e Human, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo, Ratto e Maiale.
Informazioni su geni e proteine
Riepilogo UniProt
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).
Sommario di Entrez
This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 2 family.
Modifica post-translazionale
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
Posizione cellulare
Cell membrane.
