GBP1 è un gene codificato dal simbolo GBP1. Comunemente indicato anche come: Guanylate-binding protein 1; GTP-binding protein 1; GBP-1; Guanine nucleotide-binding protein 1; Interferon-induced guanylate-binding protein 1. GBP1 ha una massa di 67.93kDa e una lunghezza di amminoacidi di 592.
Offriamo 13 anticorpi contro GBP1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.
Sommario di Entrez
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
Somiglianze di sequenza
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
Modifica post-translazionale
Isoprenylation is required for proper subcellular location.
Posizione cellulare
Cytoplasm. Golgi apparatus membrane. Cell membrane. Secreted.
Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
