Anticorpi GATA4

19 prodotti

GATA4 è un gene codificato dal simbolo GATA4. Comunemente indicato anche come: Transcription factor GATA-4; GATA-binding factor 4. GATA4 ha una massa di 44.57kDa, una lunghezza di amminoacidi di 442, ed è implicato nella malattia: Atrial septal defect 2; Ventricular septal defect 1; Tetralogy of Fallot; Atrioventricular septal defect 4; Testicular anomalies with or without congenital heart disease.

Offriamo 19 anticorpi contro GATA4, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function (PubMed:24000169, PubMed:27984724). In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (PubMed:27984724). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
Sommario di Entrez
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants.
Coinvolgimento nella malattia
Atrial septal defect 2: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. The disease is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.

Ventricular septal defect 1: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.

Tetralogy of Fallot: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.

Atrioventricular septal defect 4: A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.

Testicular anomalies with or without congenital heart disease: A 46,XY disorder of sex development with variable clinical presentation and defects in testicular differentiation and function. Clinical features include ambiguous genitalia, fused labioscrotal folds, hypospadias, microphallus, and bilateral inguinal hernia containing gonads.
Modifica post-translazionale
Methylation at Lys-300 attenuates transcriptional activity.
Posizione cellulare
Nucleus.
Western Blot - Anti-GATA4 Antibody [ARC51718] (A305425) - Antibodies.com
(6)
Western Blot - Anti-GATA4 Antibody (A89898) - Antibodies.com
(5)
Immunofluorescence - Anti-GATA4 (phospho Ser262) Antibody (A0934) - Antibodies.com
(2)
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Western Blot - Anti-GATA4 Antibody (C10618) - Antibodies.com
(3)
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Immunofluorescence - Anti-GATA4 Antibody (B0934) - Antibodies.com
(2)
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Western Blot - Anti-GATA4 Antibody (B0935) - Antibodies.com
(2)
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Immunofluorescence - Anti-GATA4 (phospho Ser105) Antibody (A0935) - Antibodies.com
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Western Blot - Anti-GATA4 Antibody (R12-2799) - Antibodies.com
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Anti-GATA4 (P101) Antibody from Bioworld Technology (BS1747) - Antibodies.com
(2)
Western blot - GATA-4 Polyclonal Antibody from Signalway Antibody (40954) - Antibodies.com
Anti-GATA4 (R306) Antibody from Bioworld Technology (BS1998) - Antibodies.com
(2)
Western blot - GATA4 Antibody from Signalway Antibody (33773) - Antibodies.com
Western blot - GATA-4 Antibody from Signalway Antibody (21496) - Antibodies.com
Western blot - GATA4 (Phospho-Ser105) Antibody from Signalway Antibody (12044) - Antibodies.com
Western blot - GATA4 (Phospho-Ser262) Antibody from Signalway Antibody (12043) - Antibodies.com
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Western Blot - Anti-GATA4 Antibody (BPA1057) - Antibodies.com

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