GAP43 è un gene codificato dal simbolo GAP43. Comunemente indicato anche come: Neuromodulin; Axonal membrane protein GAP-43; Growth-associated protein 43; Neural phosphoprotein B-50; pp46. GAP43 ha una massa di 24.8kDa e una lunghezza di amminoacidi di 238.
Offriamo 19 anticorpi contro GAP43, allevati nel Coniglio, Topo e Pollo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo, Ratto, Bovino, Maiale, Scimmia, Pollo, Cane, Gatto, Cavallo, Xenopus e Zebrafish.
Informazioni su geni e proteine
Riepilogo UniProt
This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Sommario di Entrez
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Somiglianze di sequenza
Belongs to the neuromodulin family.
Modifica post-translazionale
Phosphorylated (By similarity). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity).
Posizione cellulare
Cell membrane. Cell projection > Growth cone membrane. Cell junction > Synapse. Cell projection > Filopodium membrane. Perikaryon. Cell projection > Dendrite. Cell projection > Axon. Cytoplasm.
Cytoplasmic surface of growth cone and synaptic plasma membranes.
