GAK è un gene codificato dal simbolo GAK. È noto anche come Cyclin-G-associated kinase. GAK ha una massa di 143.19kDa e una lunghezza di amminoacidi di 1311.
Offriamo 6 anticorpi contro GAK, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e IP con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Sommario di Entrez
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.
Specificità del tessuto
Ubiquitous. Highest in testis.
Somiglianze di sequenza
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Posizione cellulare
Cytoplasm > Perinuclear region. Golgi apparatus > trans-Golgi network. Cell junction > Focal adhesion.
Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
