GABA A Receptor alpha 4 è un gene codificato dal simbolo GABRA4. Comunemente indicato anche come: Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor subunit alpha-4; GABRA4. GABA A Receptor alpha 4 ha una massa di 61.62kDa e una lunghezza di amminoacidi di 554.
Offriamo 6 anticorpi contro GABA A Receptor alpha 4, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Sommario di Entrez
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
Somiglianze di sequenza
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.
Posizione cellulare
Cell junction > Synapse > Postsynaptic cell membrane. Cell membrane.
