FSH Receptor è un gene codificato dal simbolo FSHR. Altri nomi includono: Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor; FSHR; LGR1. FSH Receptor ha una massa di 78.27kDa, una lunghezza di amminoacidi di 695, ed è implicato nella malattia: Ovarian dysgenesis 1; Ovarian hyperstimulation syndrome.
Offriamo 11 anticorpi contro FSH Receptor, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (PubMed:24058690).
Sommario di Entrez
The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants.
Specificità del tessuto
Sertoli cells and ovarian granulosa cells.
Coinvolgimento nella malattia
Ovarian dysgenesis 1: An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
Ovarian hyperstimulation syndrome: Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis.
Somiglianze di sequenza
Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
Modifica post-translazionale
Sulfated.
Posizione cellulare
Cell membrane.
