FLI1 è un gene codificato dal simbolo FLI1. Altri nomi includono: Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB. FLI1 ha una massa di 50.98kDa, una lunghezza di amminoacidi di 452, ed è implicato nella malattia: Ewing sarcoma; Bleeding disorder, platelet-type 21.
Offriamo 27 anticorpi contro FLI1, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF, Citometria a Flusso e IP con campioni derivati da Umano, Topo, Ratto e Gatto.
Informazioni su geni e proteine
Riepilogo UniProt
Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.
Sommario di Entrez
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Coinvolgimento nella malattia
Ewing sarcoma: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Bleeding disorder, platelet-type 21: A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia.
Somiglianze di sequenza
Belongs to the ETS family.
Posizione cellulare
Nucleus.
