Anticorpi Fibroblast activation protein" + " alpha

12 prodotti

Fibroblast activation protein, alpha è un gene codificato dal simbolo FAP. Altri nomi includono: Prolyl endopeptidase FAP; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; Fibroblast activation protein alpha; FAPalpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Serine integral membrane protease; SIMP; Surface-expressed protease; Seprase; FAP. Fibroblast activation protein, alpha ha una massa di 87.71kDa e una lunghezza di amminoacidi di 760.

Offriamo 12 anticorpi contro Fibroblast activation protein, alpha, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati ​​da Umano, Topo e Ratto.

Informazioni su geni e proteine

Riepilogo UniProt
Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2 (PubMed:14751930, PubMed:16223769, PubMed:16480718, PubMed:16410248, PubMed:17381073, PubMed:18095711, PubMed:21288888, PubMed:24371721). Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, vibronectin, tenascin, laminin, fibronectin, fibrin or casein (PubMed:9065413, PubMed:2172980, PubMed:7923219, PubMed:10347120, PubMed:10455171, PubMed:12376466, PubMed:16223769, PubMed:16651416, PubMed:18095711). Also has dipeptidyl peptidase activity, exhibiting the ability to hydrolyze the prolyl bond two residues from the N-terminus of synthetic dipeptide substrates provided that the penultimate residue is proline, with a preference for Ala-Pro, Ile-Pro, Gly-Pro, Arg-Pro and Pro-Pro (PubMed:10347120, PubMed:10593948, PubMed:16175601, PubMed:16223769, PubMed:16651416, PubMed:16410248, PubMed:17381073, PubMed:21314817, PubMed:24371721, PubMed:24717288). Natural neuropeptide hormones for dipeptidyl peptidase are the neuropeptide Y (NPY), peptide YY (PYY), substance P (TAC1) and brain natriuretic peptide 32 (NPPB) (PubMed:21314817). The plasma membrane form, in association with either DPP4, PLAUR or integrins, is involved in the pericellular proteolysis of the extracellular matrix (ECM), and hence promotes cell adhesion, migration and invasion through the ECM. Plays a role in tissue remodeling during development and wound healing. Participates in the cell invasiveness towards the ECM in malignant melanoma cancers. Enhances tumor growth progression by increasing angiogenesis, collagen fiber degradation and apoptosis and by reducing antitumor response of the immune system. Promotes glioma cell invasion through the brain parenchyma by degrading the proteoglycan brevican. Acts as a tumor suppressor in melanocytic cells through regulation of cell proliferation and survival in a serine protease activity-independent manner.
Sommario di Entrez
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specificità del tessuto
Expressed in adipose tissue. Expressed in the dermal fibroblasts in the fetal skin. Expressed in the granulation tissue of healing wounds and on reactive stromal fibroblast in epithelial cancers. Expressed in activated fibroblast-like synoviocytes from inflamed synovial tissues. Expressed in activated hepatic stellate cells (HSC) and myofibroblasts from cirrhotic liver, but not detected in normal liver. Expressed in glioma cells (at protein level). Expressed in glioblastomas and glioma cells. Isoform 1 and isoform 2 are expressed in melanoma, carcinoma and fibroblast cell lines.
Somiglianze di sequenza
Belongs to the peptidase S9B family.
Modifica post-translazionale
N-glycosylated.
Posizione cellulare
Cell surface. Cell membrane. Cell projection > Lamellipodium membrane. Cell projection > Invadopodium membrane. Cell projection > Ruffle membrane. Membrane.

Localized on cell surface with lamellipodia and invadopodia membranes and on shed vesicles. Colocalized with DPP4 at invadopodia and lamellipodia membranes of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Anchored and enriched preferentially by integrin alpha-3/beta-1 at invadopodia, plasma membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. Colocalized with PLAUR preferentially at the cell surface of invadopodia membranes in a cytoskeleton-, integrin- and vitronectin-dependent manner. Concentrated at invadopodia membranes, specialized protrusions of the ventral plasma membrane in a fibrobectin-dependent manner. Colocalizes with extracellular components (ECM), such as collagen fibers and fibronectin.
Western Blot - Anti-FAP-1 Antibody (C0188) - Antibodies.com
(4)
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Immunofluorescence - Anti-Fibroblast activation protein, alpha Antibody (A11961) - Antibodies.com
(4)
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4853] (A277595) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4853] - BSA and Azide free (A278183) - Antibodies.com
(4)
Visualizza prodottoAnticorpo monospecifico
ELISA - Anti-Fibroblast Activation Protein alpha Antibody [DM154] - Azide free (A318554) - Antibodies.com
(2)
Visualizza prodottoAnticorpo ricombinante
Western Blot - Anti-Fibroblast activation protein, alpha Antibody [ARC0634] (A307486) - Antibodies.com
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4851] - BSA and Azide free (A278182) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4851] (A277594) - Antibodies.com
(3)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4854] (A277596) - Antibodies.com
(2)
Visualizza prodottoAnticorpo monospecifico
Immunohistochemistry - Anti-Fibroblast Activation Protein alpha Antibody [FAP/4854] - BSA and Azide free (A278184) - Antibodies.com
(2)
Visualizza prodottoAnticorpo monospecifico
Segnaposto immagine Antibodies.com - Scopri di più spendendo meno
Western blot - Seprase Polyclonal Antibody from Signalway Antibody (41425) - Antibodies.com

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