FGF19 è un gene codificato dal simbolo FGF19. Altri nomi includono: Fibroblast growth factor 19; FGF-19. FGF19 ha una massa di 24kDa e una lunghezza di amminoacidi di 216.
Offriamo 3 anticorpi contro FGF19, allevati nel Coniglio e Human, che sono adatti per WB, ELISA e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Sommario di Entrez
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Specificità del tessuto
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Somiglianze di sequenza
Belongs to the heparin-binding growth factors family.
Posizione cellulare
Secreted.
