Ferritin Heavy Chain è un gene codificato dal simbolo FTH1. Altri nomi includono: Ferritin H subunit; Cell proliferation-inducing gene 15 protein; FTH1; FTH; FTHL6. Ferritin Heavy Chain ha una massa di 21.23kDa, una lunghezza di amminoacidi di 183, ed è implicato in Hemochromatosis 5.
Offriamo 10 anticorpi contro Ferritin Heavy Chain, allevati nel Coniglio, Topo e Capra, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Sommario di Entrez
This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.
Specificità del tessuto
Expressed in the liver.
Coinvolgimento nella malattia
Hemochromatosis 5: A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
Somiglianze di sequenza
Belongs to the ferritin family.
