Fatty Acid Binding Protein 5 è un gene codificato dal simbolo FABP5. Altri nomi includono: Fatty acid-binding protein 5; Epidermal-type fatty acid-binding protein; E-FABP; Fatty acid-binding protein, epidermal; Psoriasis-associated fatty acid-binding protein homolog; PA-FABP; FABP5. Fatty Acid Binding Protein 5 ha una massa di 15.16kDa e una lunghezza di amminoacidi di 135.
Offriamo 12 anticorpi contro Fatty Acid Binding Protein 5, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).
Sommario di Entrez
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.
Specificità del tessuto
Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585).
Somiglianze di sequenza
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Posizione cellulare
Cytoplasm. Nucleus. Cell junction > Synapse. Cell junction > Synapse > Postsynaptic density. Secreted.
Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity).
