Estrogen Sulfotransferase è un gene codificato dal simbolo SULT1E1. Altri nomi includono: Sulfotransferase 1E1; ST1E1; EST-1; Sulfotransferase, estrogen-preferring; SULT1E1; STE. Estrogen Sulfotransferase ha una massa di 35.13kDa e una lunghezza di amminoacidi di 294.
Offriamo 7 anticorpi contro Estrogen Sulfotransferase, allevati nel Coniglio e Topo, che sono adatti per WB, IHC e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7779757, PubMed:11884392, PubMed:11006110). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:7779757, PubMed:11006110).
Sommario di Entrez
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors.
Specificità del tessuto
Liver, intestine and at lower level in the kidney.
Somiglianze di sequenza
Belongs to the sulfotransferase 1 family.
Posizione cellulare
Cytoplasm > Cytosol.
