ERF è un gene codificato dal simbolo ERF. Altri nomi includono: ETS domain-containing transcription factor Ets2 repressor factor; PE-2. ERF ha una massa di 58.7kDa, una lunghezza di amminoacidi di 548, ed è implicato nella malattia: Craniosynostosis 4; Chitayat syndrome.
Offriamo 7 anticorpi contro ERF, allevati nel Coniglio, che sono adatti per WB, IHC, ELISA e ICC/IF con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity).
Sommario di Entrez
ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene.
Specificità del tessuto
Highest levels in testis, ovary, pancreas, and heart.
Coinvolgimento nella malattia
Craniosynostosis 4: A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Chitayat syndrome: An autosomal dominant syndrome characterized by hyperphalangism, partial syndactyly, bilateral accessory phalanx resulting in shortened index fingers, hallux valgus, brachydactyly, facial anomalies, diffuse bronchomalacia, and respiratory distress at birth and in infancy.
Somiglianze di sequenza
Belongs to the ETS family.
Modifica post-translazionale
Phosphorylated by multiple kinases including MAPK1/ERK2 at THR-526. Phosphorylation regulates the activity of ERF.
Posizione cellulare
Nucleus.