EPX è un gene codificato dal simbolo EPX. Altri nomi includono: Eosinophil peroxidase; EPO; EPER; EPP. EPX ha una massa di 81.04kDa, una lunghezza di amminoacidi di 715, ed è implicato in Eosinophil peroxidase deficiency.
Offriamo 11 anticorpi contro EPX, allevati nel Coniglio e Topo, che sono adatti per WB, IHC, ELISA, ICC/IF e Citometria a Flusso con campioni derivati da Umano, Topo e Ratto.
Informazioni su geni e proteine
Riepilogo UniProt
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.
Sommario di Entrez
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency.
Coinvolgimento nella malattia
Eosinophil peroxidase deficiency: A rare abnormality without clinical symptoms characterized by decreased or absent peroxidase activity and decreased volume of the granule matrix in eosinophils.
Somiglianze di sequenza
Belongs to the peroxidase family. XPO subfamily.
Posizione cellulare
Cytoplasmic granule.
Cytoplasmic granules of eosinophils.
